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Effect of inhibition of arachidonic acid metabolism on the adverse cardiovascular effects of angiotensin ii receptor blockers

  • In: Posters: Pharmacokinetics/Pharmacodynamics & Systems Pharmacology
  • At: Bangkok (Thailand) (2014)
  • Type: Poster
  • Poster code: POS-PAA005
  • By: TODA, Takaki (Hokkaido Pharmaceutical University, Clinical Pharmacology, Otaru, Japan)
  • Co-author(s): Kato, Yuka (Hokkaido Pharmaceutical University, Otaru, Japan)
    Senda, Asuna (Hokkaido Pharmaceutical University, Otaru, Japan)
    Mukai, Yuji (Hokkaido Pharmaceutical University, Otaru, Japan)
    Inotsume, Nobuo (Hokkaido Pharmaceutical University, Otaru, Japan)
  • Abstract:

    Background: Angiotensin II receptor blockers (ARBs) have adverse cardiovascular effects, including myocardial infarction, arrhythmia, palpitations and hot flashes. We have already reported that ARBs decrease the formation of epoxyeicosatrienoic acids (EETs), which are cardioprotective, from arachidonic acid by inhibiting various P450 (CYP) enzymes ..

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Last update 28 September 2023

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