Glucosidation and glucuronidation represent parallel metabolic pathways for the metabolism of mycophenolic acid and morphine by human udp-glucuronosyltransferases
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: CHAU, Nuy (Flinders University, Clinical Pharmacology, Bedford park, Australia)
- Co-author(s): Mackenzie, Peter (Flinders University, Bedford park, Australia)
Miners, John (Flinders University, Bedford park, Australia)
Several drugs are known to form both glucuronide and glucoside conjugates in vivo. Morphine forms 3- and 6-glucuronides and the 3-glucoside, while mycophenolic acid (MPA) primarily forms a phenolic glucuronide and glucoside. This study aimed to characterise the comparative kinetics of morphine and MPA conjugation with glucuronic acid and glucose.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.