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Glucosidation and glucuronidation represent parallel metabolic pathways for the metabolism of mycophenolic acid and morphine by human udp-glucuronosyltransferases

  • In: SUBMITTED ORALS on Wednesday, 16 April 2014, 14:00-15:30
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Presentation
  • By: CHAU, Nuy (Flinders University, Clinical Pharmacology, Bedford park, Australia)
  • Co-author(s): Mackenzie, Peter (Flinders University, Bedford park, Australia)
    Miners, John (Flinders University, Bedford park, Australia)
  • Abstract:

    Several drugs are known to form both glucuronide and glucoside conjugates in vivo. Morphine forms 3- and 6-glucuronides and the 3-glucoside, while mycophenolic acid (MPA) primarily forms a phenolic glucuronide and glucoside. This study aimed to characterise the comparative kinetics of morphine and MPA conjugation with glucuronic acid and glucose..

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Last update 4 October 2019

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