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Human biliary excretion of unchanged drug can be predicted prior to human dosing

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: HOSEY, Chelsea (University of California, San Francisco, Bioengineering and Therapeutic Sciences, San francisco, United States of America)
  • Co-author(s): Benet, Leslie Z. (University of California, San Francisco, San francisco, United States of America)
  • Abstract:

    Background: Metabolism and biliary elimination of parent drug are two major routes of drug elimination, affecting drug exposure, possible drug interactions, and adverse events. The primary route of elimination is difficult to predict prior to human dosing, though extensively metabolized drugs are highly permeable in humans.
    Aims: This project's..

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Last update 4 October 2019

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