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Influence of hpmc on dissolution and supersaturation characteristics

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: RUFF, Aaron (Goethe University, Institute for Pharmaceutical Technology, Frankfurt am main, Germany)
  • Co-author(s): Kesisoglou, Filippos (Merck & Co., Inc., Whitehouse station, United States of America)
    Wang, Michael (Merck & Co., Inc., Whitehouse station, United States of America)
    Xu, Wei (Merck & Co., Inc., Whitehouse station, United States of America)
    Dressman, Jennifer (Goethe University, Frankfurt am main, Germany)
  • Abstract:

    Background
    Most new drugs in development exhibit solubility limited bioavailability. One way to bypass this limitation is to promote and extend the duration of supersaturation in the small intestine. As an excipient, HPMC is known to increase the solubility and dissolution behavior of poorly soluble drugs and to have a direct influence of the..

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Last update 4 October 2019

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