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Comparative bioavailability of two brands of oral sustained-release nitroglycerin tablets

  • In: SIG: Bioavailability/Bioequivalence - Posters
  • At: Basel (Switzerland) (2008)
  • Type: Poster
  • Poster code: BB-P-012
  • By: GHANDFOROUSH-SATTARI, Mohammadreza (Tabriz University of Medical Sciences, Tabriz, Iran)
  • Co-author(s): Valizadeh, Hadi (Tabriz University of Medical Sciences, TABRIZ, Iran)
    Zakeri, Parvin (Tabriz University of Medical Sciences, TABRIZ, Iran)
    Mashayekhi, Siminozar (Hematology and Oncology Research Centre, Tabriz, Iran, Iran)
  • Abstract:

    Nitroglycerin (GTN, glyceryl trinitrate) has been used in the treatment of angina pectoris for more than a century. Following oral administration, GTN undergoes extensive first pass hepatic metabolism, thus for the pharmacokinetic study of oral GTN, its main two stable metabolites; 1,2-dinitroglycerin (1,2-GDN) and 1,3-dinitroglycerin (1,3-GDN)..

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Last update 4 October 2019

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