DESIGN OF PROTEIN KINASE INHIBITORS USING THE NATURALLY OCCURRING ISOJACAREUBIN SCAFFOLD AS A LEAD

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• Poster code: POS-DDD-010
• By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
• Co-author(s): Jeanelle Caruana: Pharmacy, University of Malta, Msida, Malta
  Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  
• Abstract:

  Background

  Protein Kinase C (PKc) is a druggable target for the mitigation of proliferative malignant disease. Isojacareubin (ISJ) is a naturally occurring molecule that has been shown to be a high affinity PKc antagonist.

  Methods

  X-ray crystallographic deposition 2IOE describing the holo- bisindolylmaleimide (BIM) inhibitor:PKc complex was

  ..

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