Pharmacokinetics and pharmacodynamics of new purine-2,6-dione–based pde4/7 inhibitors in rats

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-PAA-015
• By: WYSKA, Elzbieta (Jagiellonian University Medical College, Department of Pharmacokinetics and Physical Pharmacy)
• Co-author(s): Elżbieta Wyska
  Artur Świerczek: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, Kraków, Poland
  Krzysztof Pociecha: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, Kraków, Poland
  Marietta Ślusarczyk: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
  Agnieszka Jankowska: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
  Grażyna Chłoń-Rzepa: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
  Maciej Pawłowski: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
  
• Abstract:

  Background

  Rheumatoid arthritis (RA) is a debilitating autoimmune disorder for which no fully effective treatment exists. The encouraging results of preclinical studies on selective phosphodiesterase (PDE) 4 inhibitors using animal models of this disease has prompted us to search for new antirheumatic compounds acting as dual PDE inhibitors that

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