Olanzapine suppresses insulin secretion from pancreatic β-cells via blockade of multiple receptors

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-PAA-011
• By: NAGATA, Mao (Graduate School of Biomedical & Health Sciences, Hiroshima University, Department of Pharmaceutical Services)
• Co-author(s): Mao Nagata: Department of Pharmaceutical Services, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
  Tomoe Nakai: School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
  Yumika Miura: School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
  Takashi Tomita: Department of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Japan
  Takanori Taogoshi: Department of Pharmaceutical Services, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan;School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan;Department of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Japan
  Tomoharu Yokooji: Department of Pharmaceutical Services, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan;School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan
  Yumi Sugimoto: Department of Pharmacology, Himeji Dokkyo University, Hyogo, Japan
  Hiroaki Matsuo: Department of Pharmaceutical Services, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan;School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan;Department of Pharmaceutical Services, Hiroshima University Hospital, Hiroshima, Japan
  
• Abstract:

  Background

  Olanzapine is a potent antipsychotic agent which blocks multiple receptors such as dopamine, serotonin and histamine receptors. The use of olanzapine is sometime limited due to the induction of hyperglycemia as a side effect.

  Methods

  Expressions of dopamine (D₂, D₃ and ₄), serotonin (5-HT_2A, 5-HT_2B, 5-HT_2C and 5-HT₆) and histamine H₁
  ..

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