Effects of esomeprazole and vonoprazan on the disposition of proguanil.

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-PAA-005
• By: ITO, Kiyomi (Musashino University)
• Co-author(s): Ryohkan Funakoshi: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan;Pharmacy Administration, Kameda Medical Center, Chiba,
  Yukana Tomoda: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
  Toshiyuki Kudo: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
  Yoshiaki Yamagishi: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
  Kosho Makino: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
  Hideyo Takahashi: Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
  Kenichi Furihata: P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan
  Hiroyuki Kusuhara: Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
  Kiyomi Ito: Graduate School of Pharmaceutical Sciences, Musashino University, Tokyo, Japan
  
• Abstract:

  Background

  In vitro inhibitory effect of vonoprazan, a proton pump inhibitor, on CYP2C19 activity is much weaker than that of esomeprazole at their clinically relevant concentrations. However, in a recent clinical study, vonoprazan showed a more potent inhibition compared with esomeprazole against the antiplatelet function of clopidogrel which is..

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