Conformational studies of [3.3.1]azabicycles, synthetic analogues of norditerpenoid alkaloids
- At: Glasgow (Scotland) (2018)
- Type: Poster
- Poster code: POS-NPR-024
- By: ZENG, Ziyu (University of Bath, Pharmacy and Pharmacology)
- Co-author(s): Ziyu Zeng: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Michael Rowan: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom - Abstract:
Background
Functional group substituents on cyclohexane (A) and piperidine (E) rings in the hexacyclic norditerpenoids isolated from Aconitum and Delphinium are key to the biological activities of these alkaloids.Methods
Double Mannich reactions were used to synthesize the [3.3.1]azabicycles and then derivatives, e.g. 2,4-DNP, were prepared. The.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023