Determination of pka values of aminoglycoside primary amine groups by nmr spectroscopy

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-NPR-002
• By: AL KHZEM, Abdulaziz (University of Bath, Pharmacy and Pharmacology)
• Co-author(s): Abdulaziz Hassan Al Khzem: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  Timothy Woodman: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  
• Abstract:

  Background

  The ionisation constant (pK_a) is the pH at which functional groups are 50% ionized. Several techniques have been reported for measuring pK_a values, e.g. potentiometry, Ultraviolet (UV) spectroscopy, and Nuclear Magnetic Resonance (NMR) spectroscopy. Measurement of the pK_a values of any medication has a significant role in the..

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