Epigallocatechin-3-gallate prevents acute gout by suppressing nlrp3 inflammasome activation

• In: Oral presentation on Wednesday, 13 September 2017, 09:00-12:00
• At: Seoul (South Korea) (2017)
• Type: Presentation
• By: LEE, Hye Eun (The catholic university of Korea, college of pharmacy, Bucheon-si, Korea, Republic Of)
• Co-author(s): Hye Eun Lee:
  Gabsik Yang: college of pharmacy, The catholic university of Korea, Bucheon-si, Korea, Republic Of
  Joo Young Lee: college of pharmacy, The catholic university of Korea, Bucheon-si, Korea, Republic Of
  
• Abstract:

  Methods

  To determine the activation of inflammasomes, the degradation of pro-caspase-1 to caspase-1(p10) and the cleavage of pro-IL-1β to IL-1β were analysed by immunoblotting in mouse bone marrow-derived primary macrophages (BMDMs). The secretion of IL-1β was also determined by ELISA. A gout mouse model was generated by injecting MSU crystals

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