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Study on the conversion of novel drug potassium 2-(1-hydroxypentyl)-benzoate (dl-phpb), a pro-drug of 3-n-butylphthalide (dl-nbp)

  • In: SIG Bioavailability/Bioequivalence - Posters
  • At: Beijing (China) (2007)
  • Type: Poster
  • Poster code: BB-P-004
  • By: JIANG, Li (Institute of Meteria Medica, Beijing, China)
  • Co-author(s): XU, shaofeng (Institute of Meteria Medica, BEIJING, China)
    Wang, ling (Institute of Meteria Medica, BEIJING, China)
    Wang, xiaoliang (Institute of Meteria Medica, BEIJING, China)
  • Abstract:

    Dl-NBP is a novel agent for treatment of brain ischemia. PHPB, a potential prodrug of dl-NBP, was designed to increase water solubility of dl-NBP, which can be administrated intravenously and orally. The conversion of PHPB to dl-NBP was investigated in vitro and in vivo. To determine the level of PHPB and active drug dl-NBP, the HPLC method was..

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Last update 4 October 2019

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