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Relaxing effects of novel benzodiazepine-like ligand mp-iii-058 on rat trachea

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: NMS-015
  • By: GOLIć JELIć, Ana (Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, United States)
  • Co-author(s): Mrs Milica Gajić Bojić, Centre for Biomedical Research (Medical Faculty, University of Banja Luka, Banja Luka, Bosnia and Herzegovina)
    Dr Ana Golić Jelić, Department of pharmacology, toxicology and clinical pharmacology (Medical Faculty, University of Banja Luka, Banja Luka, Bosnia and Herzegovina)
    Dr Md Yeunus Mian, Department of Chemistry and Biochemistry (Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, United States)
    Dr Dishary Sharmin, Department of Chemistry and Biochemistry (Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, United States)
    Prof. dr James M Cook, Department of Chemistry and Biochemistry (Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, United States)
    Prof. dr Miroslav Savić, Department of Pharmacology (Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia)
  • Abstract:

    Background: Selective modulation of GABAA receptors has become increasingly important as a potential therapeutic option for the treatment of obstructive pulmonary disease. Since GABAA receptors, as pentameric ligand-gated Cl-channels with a repertoire of α subunits 1-6, express only the α4 and α5 subunit in human airway smooth muscle (ASM),..

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Last update 28 September 2023

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