Design and optimisation of novel MEK inhibitors for the management of neoplastic disease using the tak-733 scaffold as a lead molecule

• At: Seville (Spain) (2022)
• Type: Poster
• Poster code: APS-079
• By: SHOEMAKE, Claire ()
• Co-author(s): Mr Roderick Micallef, Pharmacy
  Dr Claire Shoemake, Senior Lecturer
  
• Abstract:

  The mitogen-activated protein kinase signalling pathway is dysregulated in numerous human malignancies. Mutations exert their oncogenic activity through downstream proteins such as the MEK1/2 protein kinases. MEK inhibitors have been approved for clinical use in the treatment of BRAF-mutated melanoma, and are undergoing clinical trials for the..

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