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Direct n1-selective alkylation of hydantoins using potassium bases

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: NMS-020
  • By: KUMAMOTO, Takuya (Hiroshima University, Japan)
  • Co-author(s): Prof Takuya Kumamoto (Hiroshima University, Hiroshima, Japan)
    Yumi Shintani (Hiroshima University, Hiroshima, Japan)
    Dr Koichi Kato (National Center of Neurology and Psychiatry, Kodaira, Japan)
    Dr Masashi Kawami (Hiroshima University, Hiroshima, Japan)
    Prof Mikihisa Takano (Hiroshima University, Hiroshima, Japan)
  • Abstract:

    Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. Due to the higher acidity of its proton, N³ can be more easily alkylated than N¹ under basic conditions. In this study, we explored methods for direct N¹-selective methylation of phenytoin and found that..

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Last update 28 September 2023

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