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Stability of oxytocin: aqueous vs. solid state

  • In: Posters D - Formulation Design and Pharmaceutical Technology
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • Poster code: PD-079
  • By: NASSTA, Gemma (Monash University, Drug Delivery, Disposition and Dynamics, Melbourne, Australia)
  • Co-author(s): Michelle, Mcintosh (Monash University, Melbourne, Australia)
    Morton, David (Monash University, Melbourne, Australia)
    Prankerd, Richard (Monash University, Melbourne, Australia)
  • Abstract:

    Introduction: The degradation mechanisms of a disulphide bond-containing peptide, oxytocin (OT), are currently open to speculation. Peptides and proteins containing disulphide bonds have been shown to undergo degradation via two distinct mechanisms: β-elimination, catalysed by hydroxide ions, followed by disulphide exchange. As the disulphide..

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Last update 4 October 2019

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