Application of fenofibrate solid dispersion for bioavailability enhancement by hot-melt extrusion
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: LIU, Amy (Industrial Technology Research Institute, 1. Pharmaceutical Optimization Technology Division, Biomedical Technology and De, Hsinchu, China Taiwan)
Low aqueous solubility for BCS II drugs resulted in poor oral bioavailability has been recognized as an increasingly challenge in the pharmaceutical industry. Hot-melt extrusion is one of the scale-up processes of the solid dispersion preparation in the pharmaceutical industry. The objective of this study was to improve the dissolution rate and.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.