Stability of oxytocin: aqueous vs. solid state
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: NASSTA, Gemma (Monash University, Drug Delivery, Disposition and Dynamics, Melbourne, Australia)
- Co-author(s): Michelle, Mcintosh (Monash University, Melbourne, Australia)
Morton, David (Monash University, Melbourne, Australia)
Prankerd, Richard (Monash University, Melbourne, Australia)
Introduction: The degradation mechanisms of a disulphide bond-containing peptide, oxytocin (OT), are currently open to speculation. Peptides and proteins containing disulphide bonds have been shown to undergo degradation via two distinct mechanisms: β-elimination, catalysed by hydroxide ions, followed by disulphide exchange. As the disulphide.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.