Preparation and evaluation of solid dispersion for nitrendipine-aerosil systems using melt-mixing method
- At: 2005 FIP Congress in Cairo (Egypt)
- Type: Poster
- By: WANG (-, Nagoya, Japan)
- Co-author(s): Cui (Shenyang Pharmaceutical Univ., SHENYANG, China)
Sunada (Meijo University, NAGOYA, Japan)
Nitrendipine (NTD), a dihydropyridine calcium channel blocking agent, is used to treat a variety of cardiovascular disorders. Due to its low aqueous solubility (about 2µg/mL), leading to the poor absorption of nitrendipine after oral administration, we prepared solid dispersions of nitrendipine to improve its dissolution rate and.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.