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Preparation and evaluation of solid dispersion for nitrendipine-aerosil systems using melt-mixing method

  • At: 2005 FIP Congress in Cairo (Egypt)
  • Type: Poster
  • By: WANG (-, Nagoya, Japan)
  • Co-author(s): Cui (Shenyang Pharmaceutical Univ., SHENYANG, China)
    Sunada (Meijo University, NAGOYA, Japan)
  • Abstract:

    Introduction

    Nitrendipine (NTD), a dihydropyridine calcium channel blocking agent, is used to treat a variety of cardiovascular disorders. Due to its low aqueous solubility (about 2µg/mL), leading to the poor absorption of nitrendipine after oral administration, we prepared solid dispersions of nitrendipine to improve its dissolution rate and..

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Last update 4 October 2019

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