Preparation and evaluation of solid dispersion for nitrendipine-aerosil systems using melt-mixing method

• In: Industrial Pharmacy Section - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: IPS-P-024
• By: WANG (-, Nagoya, Japan)
• Co-author(s): Cui (Shenyang Pharmaceutical Univ., SHENYANG, China)
  Sunada (Meijo University, NAGOYA, Japan)
  
• Abstract:

  Introduction
  
  Nitrendipine (NTD), a dihydropyridine calcium channel blocking agent, is used to treat a variety of cardiovascular disorders. Due to its low aqueous solubility (about 2µg/mL), leading to the poor absorption of nitrendipine after oral administration, we prepared solid dispersions of nitrendipine to improve its dissolution rate and..

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