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Analysis of interactions between HLA proteins and drug molecules which lead to the development of idiosyncratic adverse reactions.

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: NAGAYA, Nishiki (The University of Tokyo Hospital, Department of Pharmacy, Tokyo, Japan)
  • Co-author(s): Nishiki Nagaya: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Masashi Honma: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan;Laboratory of Pharmacology and Pharmacokinetics, The University of Tokyo Hospital, Tokyo, Japan
    Yoshiaki Kariya: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Tomoki Kato: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Yuki Ikebuchi: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
    Hiroshi Suzuki: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  • Abstract:

    Backgrounds

    Various idiosyncratic adverse drug reactions have been reported to be associated with human leukocyte antigen (HLA) genotypes, however; the underlying molecular mechanisms of these associations have remained to be elucidated. To date, the detailed mechanisms were demonstrated only in the case of abacavir-induced hypersensitivity..

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Last update 4 October 2019

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