Analysis of interactions between HLA proteins and drug molecules which lead to the development of idiosyncratic adverse reactions.

• At: 2017 FIP Congress in Stockholm (Sweden)
• Type: Poster
• By: NAGAYA, Nishiki (The University of Tokyo Hospital, Department of Pharmacy, Tokyo, Japan)
• Co-author(s): Nishiki Nagaya: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  Masashi Honma: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan;Laboratory of Pharmacology and Pharmacokinetics, The University of Tokyo Hospital, Tokyo, Japan
  Yoshiaki Kariya: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  Tomoki Kato: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  Yuki Ikebuchi: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  Hiroshi Suzuki: Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan
  
• Abstract:

  Backgrounds

  Various idiosyncratic adverse drug reactions have been reported to be associated with human leukocyte antigen (HLA) genotypes, however; the underlying molecular mechanisms of these associations have remained to be elucidated. To date, the detailed mechanisms were demonstrated only in the case of abacavir-induced hypersensitivity..

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