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Acamprosate has no impact on the permeability of paracellular markers across Caco-2 cells

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Poster
  • By: ANTONESCU, Irina (University of Southern Denmark, Department of Physics, Chemistry and Pharmacy, Odense, Denmark)
  • Co-author(s): Irina Antonescu: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark
    Sibylle Neuhoff: Simcyp Ltd., a Certara company, Sheffield, United Kingdom
    Bente Steffansen: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark
  • Abstract:

    Backgrounds

    The oral bioavailability of poorly permeable and non-metabolised acamprosate (BCS III) is 11%. It is controversial whether the intestinal effective permeability of the fully an-ionized acamprosate (pKa 1.83; MW 181.2 g/mol) is predominantly paracellular (Ppara) or transcellular. An initial physiologically-based pharmacokinetic model..

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Last update 4 October 2019

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