Acamprosate has no impact on the permeability of paracellular markers across Caco-2 cells

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-062-Monday
• By: ANTONESCU, Irina (University of Southern Denmark, Department of Physics, Chemistry and Pharmacy, Odense, Denmark)
• Co-author(s): Irina Antonescu: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark
  Sibylle Neuhoff: Simcyp Ltd., a Certara company, Sheffield, United Kingdom
  Bente Steffansen: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark
  
• Abstract:

  Backgrounds

  The oral bioavailability of poorly permeable and non-metabolised acamprosate (BCS III) is 11%. It is controversial whether the intestinal effective permeability of the fully an-ionized acamprosate (pKa 1.83; MW 181.2 g/mol) is predominantly paracellular (P_para) or transcellular. An initial physiologically-based pharmacokinetic model..

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