Microtubule-targeting anticancer drugs induce human P-glycoprotein
- At: 2016 FIP Congress in Buenos Aires (Argentina)
- Type: Poster
- By: NABEKURA, Tomohiro (Aichi Gakuin University, School of Pharmacy, Nagoya, Japan)
- Co-author(s): Tomohiro NABEKURA:|Tatsuya KAWASAKI:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan|Misuzu JIMURA:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan|Yuichi UWAI:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan
P-glycoprotein (MDR1/ABCB1) is a membrane transport protein that is expressed in intestine, liver, kidney, placenta, and blood-brain barrier. P-glycoprotein excludes various clinically important drugs, such as verapamil, digoxin, tacrolimus, and vinblastine, from the cells. Therefore, human P-glycoprotein plays important roles in drug.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.