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Microtubule-targeting anticancer drugs induce human P-glycoprotein

  • At: 2016 FIP Congress in Buenos Aires (Argentina)
  • Type: Poster
  • By: NABEKURA, Tomohiro (Aichi Gakuin University, School of Pharmacy, Nagoya, Japan)
  • Co-author(s): Tomohiro NABEKURA:|Tatsuya KAWASAKI:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan|Misuzu JIMURA:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan|Yuichi UWAI:School of Pharmacy,Aichi Gakuin University,Nagoya,Japan
  • Abstract:

    P-glycoprotein (MDR1/ABCB1) is a membrane transport protein that is expressed in intestine, liver, kidney, placenta, and blood-brain barrier.  P-glycoprotein excludes various clinically important drugs, such as verapamil, digoxin, tacrolimus, and vinblastine, from the cells.  Therefore, human P-glycoprotein plays important roles in drug..

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Last update 4 October 2019

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