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Polyethylenimine-based antisense oligodeoxynucleotides of il-4 suppress the production of il-4 in a murine model of airway inflammation

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: KIM, Chong-Kook (Seoul National University, Seoul, South-Korea)
  • Abstract:

    Purpose. Interleukin-4 (IL-4) plays a crucial role as an inflammatory mediator in allergic asthma via inducing Th2 inflammation, IgE synthesis, and eotaxin. To develop an effective therapeutic agent which specifically inhibits production of IL-4, antisense-oligodeoxynucleotides (AS-ODNs) against murine IL-4 mRNA were generated and complexed with..

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Last update 4 October 2019

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