Polyethylenimine-based antisense oligodeoxynucleotides of il-4 suppress the production of il-4 in a murine model of airway inflammation
- At: 2006 FIP Congress in Salvadore (Brazil)
- Type: Poster
- By: KIM, Chong-Kook (Seoul National University, Seoul, South-Korea)
Purpose. Interleukin-4 (IL-4) plays a crucial role as an inflammatory mediator in allergic asthma via inducing Th2 inflammation, IgE synthesis, and eotaxin. To develop an effective therapeutic agent which specifically inhibits production of IL-4, antisense-oligodeoxynucleotides (AS-ODNs) against murine IL-4 mRNA were generated and complexed with.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.