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Sirtuin 2 inhibitory activity of functionalized tetrahydro-y-carbolines.

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: GO, Mei Lin (Singapore, Singapore)
  • Co-author(s): Yang (, Singapore, Singapore)
    Chen, X. (, Singapore, Singapore)
    Jin (, Singapore, Singapore)
  • Abstract:

    Background:
    Sirtuins (SIRTs) are a class of histone deacetylases (HDACs) that are involved in removing acetyl groups from acetylated lysine residues in histone and non-histone proteins. Unlike other HDACs that catalyze this reaction through zinc mediated hydrolysis, sirtuins are dependent on NAD for deacetylation. There is increasing interest in..

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Last update 4 October 2019

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