Sirtuin 2 inhibitory activity of functionalized tetrahydro-y-carbolines.
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: GO, Mei Lin (Singapore, Singapore)
- Co-author(s): Yang (, Singapore, Singapore)
Chen, X. (, Singapore, Singapore)
Jin (, Singapore, Singapore)
Sirtuins (SIRTs) are a class of histone deacetylases (HDACs) that are involved in removing acetyl groups from acetylated lysine residues in histone and non-histone proteins. Unlike other HDACs that catalyze this reaction through zinc mediated hydrolysis, sirtuins are dependent on NAD for deacetylation. There is increasing interest in.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.