Sirtuin 2 inhibitory activity of functionalized tetrahydro-y-carbolines.

• In: SUBMITTED ORALS on Tuesday, 15 April 2014, 14:30-15:30
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: GO, Mei Lin (Singapore, Singapore)
• Co-author(s): Yang (, Singapore, Singapore)
  Chen, X. (, Singapore, Singapore)
  Jin (, Singapore, Singapore)
  
• Abstract:

  Background:
  Sirtuins (SIRTs) are a class of histone deacetylases (HDACs) that are involved in removing acetyl groups from acetylated lysine residues in histone and non-histone proteins. Unlike other HDACs that catalyze this reaction through zinc mediated hydrolysis, sirtuins are dependent on NAD for deacetylation. There is increasing interest in..

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