Getting past the blood-brain barrier to improve the treatment of diseases of the central nervous system

• In: 8D1 - Exploiting scientific knowledge of biological transporters for practical therapeutic benefit on Thursday, 4 October 2012, 09:00-12:00
• At: Amsterdam (the Netherlands) (2012)
• Type: Presentation
• By: HAMMARLUND-UDENAES, Margareta (Uppsala University, Department of Pharmaceutical Biosciences, Uppsala, Sweden)
• Abstract:

  AbstractThe blood-brain barrier (BBB) is made up of the endothelial cells of the capillaries in the brain. Apart from its tight junctions it also has efflux transporters like P-glycoprotein that keep many drugs out of the brain, and other uptake transporters that promotes uptake of some drugs into the brain. Knowledge about the role of drug

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