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DESIGN OF PROTEIN KINASE INHIBITORS USING THE NATURALLY OCCURRING ISOJACAREUBIN SCAFFOLD AS A LEAD
- At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
- Type: Poster
- By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
- Co-author(s): Jeanelle Caruana: Pharmacy, University of Malta, Msida, Malta
Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
BackgroundProtein Kinase C (PKc) is a druggable target for the mitigation of proliferative malignant disease. Isojacareubin (ISJ) is a naturally occurring molecule that has been shown to be a high affinity PKc antagonist.
X-ray crystallographic deposition 2IOE describing the holo- bisindolylmaleimide (BIM) inhibitor:PKc complex was.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 4 October 2019