Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome p450 enzymes: a molecular dynamics study
- In: SUBMITTED ORALS on Wednesday, 16 April 2014, 14:00-15:30
- At: PSWC, Melbourne (Australia) (2014)
- Type: Presentation
- By: NAIR, Pramod (Flinders University of South Australia, Clinical Pharmacology, Adelaide, Australia)
- Co-author(s): Miners, John O. (Flinders University of South Australia, Adelaide, Australia)
Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.