Development of fret based probe to detect conformational change of vla4 for visualizing cell adhesion
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: HIGUCHI, Yuriko (Kyoto University, The center for the promotion of interdisciplinary education and research: C-PIER, Kyoto, Japan)
- Co-author(s): Sugihara, Yuka (Kyoto University, Kyoto, Japan)
Yamashita, Fumiyoshi (Kyoto University, Kyoto, Japan)
Hashida, Mitsuru (Kyoto University, Kyoto, Japan)
Very late antigen-4 (VLA4, integrin α4β1), which expresses on leucocyte, T cell or mesenchymal stem cells, regulates their homing and tissue selective adhesion to endothelial cells. In these processes, integrin changed its structure in the bent or extended conformation. During a bent conformation, integrin can bind with VCAM1.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.