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Transplacental pharmacokinetics of lamivudine is not affected by abc drug efflux transporters

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: CECKOVA, Martina (Charles University, Faculty of Pharmacy, Dpt. of Pharmacology and Toxicology, Hradec kralove, Czech Republic)
  • Co-author(s): Neumanova, Zuzana (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
    Reznicek, Josef (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
    Cerveny, Lukas (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
    Staud, Frantisek (Charles University, Faculty of Pharmacy, Hradec kralove, Czech Republic)
  • Abstract:

    Lamivudine (3TC) is an antiretroviral drug commonly used in pregnant women to prevent vertical transmission of HIV infection. Detailed knowledge on mechanisms involved in transplacental transport of the drug is necessary for evaluation of drug-drug interactions and optimization of pharmacotherapy in pregnancy. Several drug efflux transporters of..

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Last update 4 October 2019

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