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Radical scavenging activity of benzbromarone as a novel property in vitro

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: KADOWAKI, Daisuke (Faculty of Pharmaceutical Sciences, Kumamoto University, Department of Clinical Pharmacology, Kumamoto, Japan)
  • Co-author(s): Sakaguchi, Shoichi (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Miyamoto, Yohei (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Muraya, Nanako (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Narita, Yuki (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Sato, Keizo (School of Pharmacy, Kyushu University of Health and Welfare, Nobeoka, Japan)
    Ishima, Yu (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Chuang, Victor (School of Pharmacy, Faculty of Health Sciences, Curtin University, Perth, Australia)
    Maruyama, Toru (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
    Otagiri, Masaki (Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan)
    Hirata, Sumio (Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan)
  • Abstract:

    [Background] Uric acid plays an important role in the antioxidant effect against external oxidative stress at physiological blood concentration. However, uric acid can increase reactive oxygen species (ROS) production via NADPH oxidase activation in a concentration-dependent manner in adipocytes and vascular cells, and uric acid transporter 1..

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Last update 4 October 2019

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