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Effect of albumin on transthyretin disposition and tissue deposition in vivo

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: TAGUCHI, Kazuaki (Sojo University, Faculty of Pharmaceutical Sciences, Kumamoto, Japan)
  • Co-author(s): Nagao, Saori (Kumamoto university, Kumamoto, Japan)
    Jono, Hirofumi (Department of Pharmacy, Kumamoto University Hospital, Kumamoto, Japan)
    Yamasaki, Keishi (Sojo University, Kumamoto, Japan)
    Mizuguchi, Mineyuki (Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan)
    Maruyama, Toru (Kumamoto university, Kumamoto, Japan)
    Ando, Yukio (Department of Neurology, Kumamoto Universit, Kumamoto, Japan)
    Otagiri, Masaki (Sojo University, Kumamoto, Japan)
  • Abstract:

    [Background] Transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP) is characterized by the systemic accumulation of amyloid fibrils caused by amyloidogenic. It was reported that albumin played a role in the inhibition of TTR amyloid-formation. [Aims] The aim of this study was to evaluate the effect of albumin on amyloidogenic TTR..

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Last update 4 October 2019

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