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Design, synthesis and antitumor activity research of psammaplin a derivatives

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: LIU, Dan (Shenyang Pharmaceutical University, Shenyang, China)
  • Co-author(s): Wen, Jiachen (Shenyang Pharmaceutical University, Shenyang, China)
    Jiang, Tao (Shenyang Pharmaceutical University, Shenyang, China)
    Zhao, Linxiang (Shenyang Pharmaceutical University, Shenyang, China)
  • Abstract:

    Background: Histone deacetylases (HDACs) and DNA methyltransferase (DNMT) are the key enzymes for epigenetics alterations. The marine natural product Psammaplin A (PSA), which was reported to inhibit HDACs (IC50 = 4.2 nM) and DNMTs (IC50 = 18.6 nM) was taken as leading compound. A series of PSA derivatives were designed and synthesized, the..

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Last update 4 October 2019

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