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Utility of plasma as transport medium in the caco-2 monolayer test system

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: KATNENI, Kasiram (Monash Institute of Pharmaceutical Sciences, Monash University, Centre for Drug Candidate Optimisation, Parkville, Australia)
  • Co-author(s): Pham, Thao (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
    Saunders, Jessica (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
    Campbell, Anna (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
    Shackleford, David (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
    Charman, Susan (Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia)
  • Abstract:

    Background and Aim: The reliability of in vitro permeability measurements for lipophilic compounds is often hindered by poor mass balance and lack of sink conditions. We herein describe the use of plasma as a transport medium in Caco-2 permeability studies as a means to overcome these issues.
    Methods: The Caco-2 permeability of a range of marker..

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Last update 4 October 2019

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