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Gene therapy: pegylation of cationic dna lipoplexes can increase the distribution and transfection efficiency in the muscle

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: HO, Joan (Monash University, Drug Discovery Biology, Melbourne, Australia)
  • Co-author(s): White, Paul (Monash University, Melbourne, Australia)
    Pouton, Colin (Monash University, Melbourne, Australia)
  • Abstract:

    Background Genetic diseases of the skeletal muscle, such as muscular dystrophy, can lead to the progressive weakening and degeneration of the muscle. Gene therapy has been trialled as a treatment option; however, due to the poor transfection efficiency of plasmid DNA in the muscle, the effectiveness of this therapy is still relatively low. Aim Our

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Last update 4 October 2019

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