Discovery and indentification of new PIN1 inhibitors
- At: 2013 FIP Congress in Dublin (Ireland)
- Type: Poster
- By: ZHANG, Jing (Nstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, The National Laboratory for Screening New Microbial Drugs, Beijing, China)
: PIN1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase (PPIase) family of proteins. Following phosphorylation, Pin1 catalyzed prolyl-isomerization induces conformational changes and thereby regulates the function of a number of phosphorylated proteins that play an important role during oncogenesis.
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