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Development of transparent ibuprofen-loaded solution with enhanced oral bioavailability using poloxamer 188 and menthol

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, South-Korea)
  • Co-author(s): Piao, Ming-Guan (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Li, Dong-Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Xuan, Jing-Ji (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kwak, Mi-Kyoung (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kim, Jung-Ae (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Lyoo, Won Seok (School of Textiles, Yeungnam University, GYEONGSAN-SI, South-Korea)
  • Abstract:

    Purpose. To develop transparent ibuprofen-loaded solution with the enhanced oral bioavailability using poloxamer and menthol. Method. The effects of menthol and poloxamer 188 on the aqueous solubility of ibuprofen were investigated. The dissolution and pharmacokinetic study of ibuprofen delivered by the poloxamer gels composed of poloxamer 188 and ..

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Last update 4 October 2019

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