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Development of diclofenac prodrugs for enhanced percutaneous absorption

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, South-Korea)
  • Co-author(s): Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kwak, Mi-Kyoung (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Rhee, Jong-Dal (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kim, Jung-Ae (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Lyoo, Won Seok (School of Textiles, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kwon, Ram (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Yang, Chan-Woo (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Park, Jung-Kil (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  • Abstract:

    Purpose. To investigate the physicochemical characterization and in vitro evaluation of alkyl ester derivatives of diclofenac as potential dermal prodrugs of diclofenac. Methods. The prodrugs of diclofenac were synthesized, and their physicochemical properties such as solubility, pKa and stability in buffered solution and in human serum were..

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Last update 4 October 2019

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