Clinical pharmacology of antibody-based therapeutics
- At: 2013 FIP Congress in Dublin (Ireland)
- Type: Presentation
- By: MAGER, Donald (University at Buffalo, SUNY, Pharmaceutical Sciences, Buffalo, NY, United States of America)
The in vivo disposition (pharmacokinetics, PK) and action (pharmacodynamics, PD) of biological therapeutics tend to be more complex relative to small synthetic compounds, resulting from a combination of pharmacological and physiological factors. Nonlinear dose-dependent effects on drug absorption, disposition, and response are commonplace... The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.