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Evaluation of the functional role of P-glycoprotein in tramadol neuropharmacokinetic

  • At: 2012 FIP Congress in Amsterdam (the Netherlands)
  • Type: Poster
  • By: SHEIKHOLESLAMI, Behjat (Tehran University of Medical Sciences, Faculty of Pharmacy, Biopharmaceutics and Pharmacokinetic Devision, Department of Pharmaceutics, Tehran, Iran)
  • Co-author(s): Hamidi, M. (Zanjan University of Medical Sciences, Faculty of Pharmacy, Zanjan, Iran)
    Lavasani, H. (Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran)
    Rouini, M.R. (Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran)
  • Abstract:


    I.


    Backgroun


    d


    :

    P-glycoprotein is one of the most important efflux transporters which is located throughout the body and always prevents the drug tissue uptake.
    II.


    Aim:

    The present study evaluates the possible functional involvement of P-gp in brain penetration of Tramadol Hydrochloride which is a widely-used centrally acting analgesic drug.
    III.


    Met

    ..

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Last update 4 October 2019

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