Preparation and solid-state characterization of nanoporous saquinavir mesylate for aqueous solubility enhancement
- At: 2011 FIP Congress in Hyderabad (India)
- Type: Poster
- By: GOVENDER, Thirumala (University of Kwazulu Natal, South Africa, Durban, South Africa)
- Co-author(s): Branham, M. (University of KwaZulu Natal, South Africa, Durban, South Africa)
Moyo, T. (School of Physics, University of KwaZulu-Natal, Durban, South Africa)
Background: Saquinavir is an anti-retroviral drug reported as an excellent P-gp and CYP3A substrate with very low oral bioavailability (e.g. 0.7-4.0%). Buccal delivery systems for saquinavir are an attractive alternative to conventional dosage forms but aqueous solubility is a key issue restricting their effective use. The aim of this study was to.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.