Preparation and solid-state characterization of nanoporous saquinavir mesylate for aqueous solubility enhancement

• In: Industrial Pharmacy Posters
• At: Hyderabad (India) (2011)
• Type: Poster
• Poster code: IPS-P-16
• By: GOVENDER, Thirumala (University of Kwazulu Natal, South Africa, Durban, South Africa)
• Co-author(s): Branham, M. (University of KwaZulu Natal, South Africa, Durban, South Africa)
  Moyo, T. (School of Physics, University of KwaZulu-Natal, Durban, South Africa)
  
• Abstract:

  Background: Saquinavir is an anti-retroviral drug reported as an excellent P-gp and CYP3A substrate with very low oral bioavailability (e.g. 0.7-4.0%). Buccal delivery systems for saquinavir are an attractive alternative to conventional dosage forms but aqueous solubility is a key issue restricting their effective use. The aim of this study was to

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