Lps-induced inflammation alters the disposition of fexofenadine in the isolated perfused rat liver.
- At: 2005 FIP Congress in Cairo (Egypt)
- Type: Poster
- By: DAVEY, Andrew (University of South Australia, Centre for Pharmaceutical Research, Adelaide, Australia)
- Co-author(s): Tong (University of South Australia, ADELAIDE, Australia)
Zhang (University of South Australia, ADELAIDE, Australia)
Ngo (University of South Australia, ADELAIDE, Australia)
AIM: To examine the effect of bacterial lipopolysaccharide (LPS) on the pharmacokinetics of fexofenadine (an OATP and P-gp substrate) in the isolated perfused liver. METHODS: Male SD rats were divided into 4 groups (n=4): 1 control group and 3 treatment groups. Inflammation was induced in the 3 treatment groups by either 5, 2.5 or 1mg/kg i.p. of.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.