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Dissolution evaluation of simvastatin capsules by alternative isocratic RP-HPLC

  • At: 2010 FIP Congress in Lisbon (Portugal)
  • Type: Poster
  • By: MARQUES-MARINHO, Flávia (Federal University of Minas Gerais, Belo Horizonte, Brazil)
  • Co-author(s): Zanon, José Carlos (Preventive Medicine Center, Mariana, Brazil)
    Reis, Ilka (Federal University of Minas Gerais, Belo Horizonte, Brazil)
    Lima, Angélica (Federal University of Ouro Preto, Ouro Preto, Brazil)
    Vianna-Soares, Cristina (Federal University of Minas Gerais, Belo Horizonte, Brazil)
  • Abstract:

    Simvastatin is a hydrophobic very slightly soluble drug in water used for the treatment of hypercholesterolemia. Because drug release is a limiting step to its efficacy the dissolution test is an important tool to drive drug development and quality control. In this study, thirty distinct compounding formulations of simvastatin 20 mg capsules were

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Last update 4 October 2019

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