In silico based structural features study of ccr5 antagonists as antihiv-1 agents
- At: 2010 FIP Congress in Lisbon (Portugal)
- Type: Poster
- By: MOORTHY, N.S. Hari Narayana (University of Porto, Porto, Portugal)
- Co-author(s): Maria J., Ramos (University of Porto, PORTO, Portugal)
Pedro a., Fernandes (University of Porto, PORTO, Portugal)
HIV-1 attachment is mediated by the interaction of the viral envelope glycoprotein gp120. The interaction of transmembrane CCR5 with viral gp120 is critical for membrane fusion and virus entry; because a blockade of such binding can inhibit HIV-1 infection efficiently. In the present investigation, the antiHIV drug discovery group in our.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.