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Simultaneous determination of lamotrigine, phenobarbitone, carbamazepine and phenytoin in human brain tissue by high-performance liquid chromatography

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: JIANG, Dechun (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
  • Co-author(s): Shen, Jiang Hua (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, BEIJING, China)
    Wang, Yuqin (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, BEIJING, China)
  • Abstract:

    Objective:To establish a method for simultaneous determination lamotrigine, phenobarbitone, carbamazepine and phenytoin concentration in brain tissue of refractory epilepsy patients. Method: the Agilent C18colum (250 mm ×4.6 mm ,5μm) was used, the mobile phase consisted of phosphate buffer (10mM)-methanol-acetonitrile-acetone in the..

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Last update 4 October 2019

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